PNPLA3-Associated Steatohepatitis: Toward a Gene-Based Classification of Fatty Liver Disease
نویسندگان
چکیده
منابع مشابه
PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.
Nonalcoholic fatty liver disease is one of the most common hepatic disorders worldwide. Given the high-calorie nutrition of children and adults, nonalcoholic fatty liver disease (NAFLD) is expected to become a major cause of cirrhosis and eventually liver transplantation. Familial clustering and ethnic differences indicate that genetic factors contribute to NAFLD. Recently, the common variant p...
متن کاملNonalcoholic fatty liver disease and the PNPLA3 gene.
Nonalcoholic fatty liver disease, a potentially fatal obesity-related condition, affects more than 70 million people in the United States. Nurses are well-positioned to impact this genetically influenced disease by is increasing awareness, providing patient education, and advocating for affected persons.
متن کاملNonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on ...
متن کاملA Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis*
Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in humans. Here we examined the effect of the I148M substitution on the enzymatic activity and cellu...
متن کاملAssociation of rs738409 Polymorphism in the PNPLA3 Gene with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated incidence of 20%–30% in the general population and 67%–75% in the obese population. Genetic predisposition can play an important role in development of this disease. Nonsynonymous coding SNP rs738409 C/G (I148Met) in the PNPLA3 gene has been found to be associated with the presence of...
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ژورنال
عنوان ژورنال: Seminars in Liver Disease
سال: 2013
ISSN: 0272-8087,1098-8971
DOI: 10.1055/s-0033-1358525